USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q14721 USC-OGP 2-DE database:  Q14721 Q14721 General information about the entry View entry in simple text format Entry name KCNB1_HUMAN Primary accession number Q14721 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Potassium voltage-gated channel subfamily B member 1 {ECO:0000312|HGNC:HGNC:6231}; AltName: Full=Delayed rectifier potassium channel 1 {ECO:0000303|PubMed:8081723}; Short=DRK1 {ECO:0000303|PubMed:8081723}; Short=h-DRK1 {ECO:0000303|PubMed:8081723}; AltName: Full=Voltage-gated potassium channel subunit Kv2.1 {ECO:0000303|PubMed:8081723};. Gene name Name=KCNB1 {ECO:0000312|HGNC:HGNC:6231} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0329: pI=5.88; Mw=63195 Cross-references UniProtKB/Swiss-Prot Q14721; KCNB1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name KCNB1_HUMAN Primary accession number Q14721 Secondary accession number(s) Q14193 Sequence was last modified on  October 25, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 149) Name and origin of the protein Description RecName: Full=Potassium voltage-gated channel subfamily B member 1 {ECO:0000312|HGNC:HGNC:6231}; AltName: Full=Delayed rectifier potassium channel 1 {ECO:0000303|PubMed:8081723}; Short=DRK1 {ECO:0000303|PubMed:8081723}; Short=h-DRK1 {ECO:0000303|PubMed:8081723}; AltName: Full=Voltage-gated potassium channel subunit Kv2.1 {ECO:0000303|PubMed:8081723}; Gene name Name=KCNB1 {ECO:0000312|HGNC:HGNC:6231} Encoded on Name=KCNB1 {ECO:0000312|HGNC:HGNC:6231 Keywords Cell junction; Cell membrane; Cell projection; Complete proteome; Disease mutation; Epilepsy; Exocytosis; Ion channel; Ion transport; Isopeptide bond; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Potassium; Potassium channel; Potassium transport; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport; Ubl conjugation; Voltage-gated channel. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X68302; CAA48374.1; -; Genomic_DNA EMBL L02840; AAA36156.1; ALT_INIT; mRNA EMBL AF026005; AAB88808.1; -; mRNA EMBL AL035685; CAB89417.1; -; Genomic_DNA CCDS CCDS13418.1; -; . PIR S31761; S31761; . RefSeq NP_004966.1; NM_004975.3; . RefSeq XP_006723847.1; XM_006723784.3; . RefSeq XP_011527101.1; XM_011528799.2; . UniGene Hs.633143; -; . UniGene Hs.84244; -; . ProteinModelPortal Q14721; -; . SMR Q14721; -; . BioGrid 109947; 15; . IntAct Q14721; 1; . STRING 9606.ENSP00000360806; -; . ChEMBL CHEMBL2363000; -; . DrugBank DB06637; Dalfampridine; . GuidetoPHARMACOLOGY 546; -; . TCDB 1.A.1.2.11; the voltage-gated ion channel (vic) superfamily; . iPTMnet Q14721; -; . PhosphoSitePlus Q14721; -; . BioMuta KCNB1; -; . DMDM 24418854; -; . OGP Q14721; -; . MaxQB Q14721; -; . PaxDb Q14721; -; . PeptideAtlas Q14721; -; . PRIDE Q14721; -; . DNASU 3745; -; . Ensembl ENST00000371741; ENSP00000360806; ENSG00000158445; . Ensembl ENST00000635465; ENSP00000489193; ENSG00000158445; . GeneID 3745; -; . KEGG hsa:3745; -; . UCSC uc002xur.2; human; . CTD 3745; -; . DisGeNET 3745; -; . GeneCards KCNB1; -; . HGNC HGNC:6231; KCNB1; . HPA CAB001979; -; . HPA HPA042434; -; . MalaCards KCNB1; -; . MIM 600397; gene; . MIM 616056; phenotype; . neXtProt NX_Q14721; -; . OpenTargets ENSG00000158445; -; . Orphanet 1934; Early infantile epileptic encephalopathy; . PharmGKB PA209; -; . eggNOG KOG3713; Eukaryota; . eggNOG COG1226; LUCA; . GeneTree ENSGT00760000118981; -; . HOGENOM HOG000113206; -; . HOVERGEN HBG052225; -; . InParanoid Q14721; -; . KO K04885; -; . OMA TEGVIDM; -; . OrthoDB EOG091G0FP3; -; . PhylomeDB Q14721; -; . TreeFam TF313103; -; . Reactome R-HSA-1296072; Voltage gated Potassium channels; . Reactome R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; . SIGNOR Q14721; -; . GeneWiki KCNB1; -; . GenomeRNAi 3745; -; . PRO PR:Q14721; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000158445; -; . CleanEx HS_KCNB1; -; . ExpressionAtlas Q14721; baseline and differential; . Genevisible Q14721; HS; . GO GO:0030424; C:axon; ISS:UniProtKB; . GO GO:0030054; C:cell junction; IEA:UniProtKB-KW; . GO GO:0030425; C:dendrite; ISS:UniProtKB; . GO GO:0005622; C:intracellular; IEA:GOC; . GO GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell; . GO GO:0032809; C:neuronal cell body membrane; ISS:UniProtKB; . GO GO:0043204; C:perikaryon; ISS:UniProtKB; . GO GO:0005886; C:plasma membrane; IDA:UniProtKB; . GO GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell; . GO GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell; . GO GO:0008076; C:voltage-gated potassium channel complex; IDA:UniProtKB; . GO GO:0005251; F:delayed rectifier potassium channel activity; IDA:UniProtKB; . GO GO:0044325; F:ion channel binding; IPI:UniProtKB; . GO GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB; . GO GO:0032182; F:ubiquitin-like protein binding; IPI:UniProtKB; . GO GO:0001508; P:action potential; IDA:UniProtKB; . GO GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB; . GO GO:0031669; P:cellular response to nutrient levels; ISS:UniProtKB; . GO GO:0042593; P:glucose homeostasis; ISS:UniProtKB; . GO GO:0007215; P:glutamate receptor signaling pathway; ISS:UniProtKB; . GO GO:0046676; P:negative regulation of insulin secretion; ISS:UniProtKB; . GO GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; ISS:UniProtKB; . GO GO:0033605; P:positive regulation of catecholamine secretion; ISS:UniProtKB; . GO GO:1900454; P:positive regulation of long term synaptic depression; ISS:UniProtKB; . GO GO:0010701; P:positive regulation of norepinephrine secretion; ISS:UniProtKB; . GO GO:0090314; P:positive regulation of protein targeting to membrane; IDA:UniProtKB; . GO GO:0071805; P:potassium ion transmembrane transport; IDA:UniProtKB; . GO GO:0051260; P:protein homooligomerization; IEA:InterPro; . GO GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB; . GO GO:0098900; P:regulation of action potential; ISS:UniProtKB; . GO GO:0050796; P:regulation of insulin secretion; TAS:Reactome; . GO GO:2000671; P:regulation of motor neuron apoptotic process; ISS:UniProtKB; . GO GO:0006904; P:vesicle docking involved in exocytosis; ISS:UniProtKB; . Gene3D 1.20.120.350; -; 1; . InterPro IPR000210; BTB/POZ_dom; . InterPro IPR027359; Channel_four-helix_dom; . InterPro IPR005821; Ion_trans_dom; . InterPro IPR003968; K_chnl_volt-dep_Kv; . InterPro IPR003973; K_chnl_volt-dep_Kv2; . InterPro IPR004350; K_chnl_volt-dep_Kv2.1; . InterPro IPR011333; SKP1/BTB/POZ; . InterPro IPR003131; T1-type_BTB; . InterPro IPR028325; VG_K_chnl; . PANTHER PTHR11537; PTHR11537; 1; . Pfam PF02214; BTB_2; 1; . Pfam PF00520; Ion_trans; 1; . Pfam PF03521; Kv2channel; 2; . PRINTS PR00169; KCHANNEL; . PRINTS PR01514; KV21CHANNEL; . PRINTS PR01491; KVCHANNEL; . PRINTS PR01495; SHABCHANNEL; . SMART SM00225; BTB; 1; . SUPFAM SSF54695; SSF54695; 1; .

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